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Protein kinase, cAMP-dependent, regulatory, type II, beta (HGNC Symbol)
Entrez gene summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
P31323 [Direct mapping] cAMP-dependent protein kinase type II-beta regulatory subunit A0A024R712 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type II, beta, isoform CRA_a
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Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0001932 [regulation of protein phosphorylation] GO:0003091 [renal water homeostasis] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005743 [mitochondrial inner membrane] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006631 [fatty acid metabolic process] GO:0006833 [water transport] GO:0006996 [organelle organization] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0007612 [learning] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030425 [dendrite] GO:0030552 [cAMP binding] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045859 [regulation of protein kinase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] GO:0097332 [response to antipsychotic drug] GO:0097338 [response to clozapine] GO:0097546 [ciliary base] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]