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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CREBBP
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

CREBBP

Gene descriptioni

Gene description according to HGNC.

CREB binding protein

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 2 antibodies.
HPA055861 , CAB004212
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA055861
CAB004212

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Most cancer tissues showed moderate to strong nuclear immunoreactivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Tumour cells generally showed moderate to strong nuclear positivity. Most cases of endometrial and gastric cancer were weakly stained or negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CREBBP (HGNC Symbol)

Synonyms

CBP, KAT3A, RSTS, RTS

Description

CREB binding protein (HGNC Symbol)

Entrez gene summary

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

3725054 - 3880726

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005339 (version 83.38)

Entrez gene

1387

UniProt

Q92793 (UniProt - Evidence at protein level)

neXtProt

NX_Q92793

Antibodypedia

CREBBP antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

CREBBP-001
CREBBP-003
CREBBP-005
CREBBP-006
CREBBP-008
CREBBP-011

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CREBBP-001
ENSP00000262367
ENST00000262367
Q92793 [Direct mapping]
CREB-binding protein
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000123 [histone acetyltransferase complex]
GO:0000790 [nuclear chromatin]
GO:0000940 [condensed chromosome outer kinetochore]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001666 [response to hypoxia]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006473 [protein acetylation]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016604 [nuclear body]
GO:0018076 [N-terminal peptidyl-lysine acetylation]
GO:0030718 [germ-line stem cell population maintenance]
GO:0032481 [positive regulation of type I interferon production]
GO:0033613 [activating transcription factor binding]
GO:0034605 [cellular response to heat]
GO:0034644 [cellular response to UV]
GO:0042592 [homeostatic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043234 [protein complex]
GO:0043426 [MRF binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0048511 [rhythmic process]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070555 [response to interleukin-1]
GO:0071456 [cellular response to hypoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:0098609 [cell-cell adhesion]
GO:1900034 [regulation of cellular response to heat]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Show all
2442 aa
265.4 kDa
No 0
CREBBP-003
ENSP00000371502
ENST00000382070
Q92793 [Direct mapping]
CREB-binding protein
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000123 [histone acetyltransferase complex]
GO:0000790 [nuclear chromatin]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001666 [response to hypoxia]
GO:0002039 [p53 binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006473 [protein acetylation]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016604 [nuclear body]
GO:0018076 [N-terminal peptidyl-lysine acetylation]
GO:0032481 [positive regulation of type I interferon production]
GO:0034605 [cellular response to heat]
GO:0034644 [cellular response to UV]
GO:0042592 [homeostatic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0043426 [MRF binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:1900034 [regulation of cellular response to heat]
Show all
2404 aa
261 kDa
No 0
CREBBP-005
ENSP00000458254
ENST00000572134
I3L0Q1 [Direct mapping]
CREB-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
254 aa
27.2 kDa
No 0
CREBBP-006
ENSP00000459490
ENST00000571826
I3L293 [Direct mapping]
CREB-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
181 aa
19 kDa
No 0
CREBBP-008
ENSP00000461002
ENST00000570939
I3L466 [Direct mapping]
CREB-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016573 [histone acetylation]
Show all
1105 aa
122.4 kDa
No 0
CREBBP-011
ENSP00000460474
ENST00000573517
I3L3I5 [Direct mapping]
CREB-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004402 [histone acetyltransferase activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016573 [histone acetylation]
Show all
196 aa
22.5 kDa
No 0

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  • DOWNLOADABLE DATA

The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.