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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
CREBBP (HGNC Symbol)
Synonyms
CBP, KAT3A, RSTS, RTS
Description
CREB binding protein (HGNC Symbol)
Entrez gene summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CREBBP-001
CREBBP-003
CREBBP-005
CREBBP-006
CREBBP-008
CREBBP-011
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000123 [histone acetyltransferase complex] GO:0000790 [nuclear chromatin] GO:0000940 [condensed chromosome outer kinetochore] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001666 [response to hypoxia] GO:0002039 [p53 binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0006473 [protein acetylation] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008589 [regulation of smoothened signaling pathway] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016604 [nuclear body] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0030718 [germ-line stem cell population maintenance] GO:0032481 [positive regulation of type I interferon production] GO:0033613 [activating transcription factor binding] GO:0034605 [cellular response to heat] GO:0034644 [cellular response to UV] GO:0042592 [homeostatic process] GO:0042733 [embryonic digit morphogenesis] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043234 [protein complex] GO:0043426 [MRF binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048511 [rhythmic process] GO:0060355 [positive regulation of cell adhesion molecule production] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070555 [response to interleukin-1] GO:0071456 [cellular response to hypoxia] GO:0090575 [RNA polymerase II transcription factor complex] GO:0098609 [cell-cell adhesion] GO:1900034 [regulation of cellular response to heat] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000123 [histone acetyltransferase complex] GO:0000790 [nuclear chromatin] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001666 [response to hypoxia] GO:0002039 [p53 binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006461 [protein complex assembly] GO:0006473 [protein acetylation] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008589 [regulation of smoothened signaling pathway] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016604 [nuclear body] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0032481 [positive regulation of type I interferon production] GO:0034605 [cellular response to heat] GO:0034644 [cellular response to UV] GO:0042592 [homeostatic process] GO:0042733 [embryonic digit morphogenesis] GO:0043426 [MRF binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:1900034 [regulation of cellular response to heat]
