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Most cancers displayed moderate to strong membranous and cytoplasmic positivity. Lymphomas, gliomas, testicular and prostate cancers were in general weakly stained or negative.
Colorectal, thyroid and pancreatic cancers along with several skin, cervical, prostate, ovarian, lung, gastric and liver cancers displayed moderate to strong cytoplasmic and membranous staining. Remaining cancers were in general negative.
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]