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Moderate nuclear membranous staining, combined with cytoplasmic positivity was observed in most malignant tissues. Several malignant gliomas, thyroid and prostate cancers were strongly stained. Ovarian, endometrial, lung and testicular cancers were weakly stained in several cases.
GENE INFORMATION
Gene name
CRY1 (HGNC Symbol)
Synonyms
PHLL1
Description
Cryptochrome circadian clock 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]