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Most cancers exhibited moderate to strong cytoplasmic positivity. Lymphomas, gliomas and prostate cancers along with several melanomas, skin, breast and testicular cancers were weakly stained or negative.
Most cancer cells displayed moderate cytoplasmic staining. Gliomas, lymphomas, melanomas, skin and lung cancers were weakly to moderately stained.
GENE INFORMATION
Gene name
ROPN1 (HGNC Symbol)
Synonyms
CT91, ODF6, ROPN1A, ropporin
Description
Rhophilin associated tail protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]