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Most of the cancer tissues showed weak to moderate nuclear and/or cytoplasmic positivity in many cases. Colorectal cancers and several pancreatic cancers showed moderate to strong membranous positivity. Most breast, prostate, ovarian, endometrial and renal cancers were negative.
Most malignant cells exhibited weak to moderate cytoplasmic immunoreactivity. A few hepatocellular carcinomas were strongly stained. Several malignant carcinoids and squamous cell carcinomas were negative.
GENE INFORMATION
Gene name
SEC31B (HGNC Symbol)
Synonyms
DKFZP434M183, SEC31B-1, SEC31L2
Description
SEC31 homolog B, COPII coat complex component (HGNC Symbol)
Entrez gene summary
This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]