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A majority of cancer tissues showed weak to moderate cytoplasmic and membranous positivity. A few cases of breast and pancreatic cancers as well as cholangiocarcinomas showed strong immunoreactivity. Gliomas, lymphomas, carcinoids, melanomas, skin, testis and renal cancers were negative.
GENE INFORMATION
Gene name
STXBP2 (HGNC Symbol)
Synonyms
Hunc18b, UNC18B
Description
Syntaxin binding protein 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]