We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most of the cancer tissues displayed moderate nuclear positivity with additional cytoplasmic staining in several cases. A few melanomas and urothelial cancers were strongly stained. Several prostate and renal cancers were weakly stained or negative.
Weak to moderate nuclear immunoreactivity was observed in most cancer tissues. Prostate cancers, several testis and stomach cancers along with squamous and basal cell carcinomas were negative.
GENE INFORMATION
Gene name
RBL1 (HGNC Symbol)
Synonyms
cp107, p107, PRB1
Description
Retinoblastoma-like 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]