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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

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Method

Validation

Method

Validation

Method

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Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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TRPM3
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

TRPM3

Gene descriptioni

Gene description according to HGNC.

Transient receptor potential cation channel, subfamily M, member 3

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Membrane

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (LHCN-M2, TIME, U-2197)
HPA (normal tissue):Tissue enhanced (kidney)

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Pending cancer tissue analysis.

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Pending cancer tissue analysis


STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

 

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

TRPM3 (HGNC Symbol)

Synonyms

GON-2, KIAA1616, LTRPC3

Description

Transient receptor potential cation channel, subfamily M, member 3 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

Chromosome location (bp)

70529063 - 71446904

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000083067 (version 83.38)

Entrez gene

80036

UniProt

Q9HCF6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9HCF6

Antibodypedia

TRPM3 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
TRPM3-002
TRPM3-005
TRPM3-006
TRPM3-007
TRPM3-008
TRPM3-009
TRPM3-010
TRPM3-011
TRPM3-012
TRPM3-014
TRPM3-015
TRPM3-016
TRPM3-201
TRPM3-202
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM3-002
ENSP00000379579
ENST00000396283
Q4VXD4 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0098655 [cation transmembrane transport]
Show all
275 aa
30.4 kDa
No 0
TRPM3-005
ENSP00000355395
ENST00000361823
Q9HCF6 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0034220 [ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
230 aa
25.2 kDa
No 0
TRPM3-006
ENSP00000366301
ENST00000377097
H0Y3D4 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005261 [cation channel activity]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0071482 [cellular response to light stimulus]
GO:0098655 [cation transmembrane transport]
Show all
123 aa
13.6 kDa
No 0
TRPM3-007
ENSP00000366315
ENST00000377111
Q9HCF6 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0034220 [ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
1325 aa
152.7 kDa
No 8
TRPM3-008
ENSP00000366314
ENST00000377110
Q9HCF6 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0034220 [ion transmembrane transport]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
Show all
1707 aa
194.7 kDa
No 8
TRPM3-009
ENSP00000379581
ENST00000396285
A2A3F3 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1566 aa
178.7 kDa
No 7
TRPM3-010
ENSP00000366305
ENST00000377101
Q504Y1 [Direct mapping]
TRPM3 protein; Transient receptor potential cation channel subfamily M member 3
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005227 [calcium activated cation channel activity]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0098655 [cation transmembrane transport]
Show all
323 aa
35.6 kDa
No 0
TRPM3-011
ENSP00000379587
ENST00000396292
E9PBI7 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1579 aa
180.2 kDa
No 7
TRPM3-012
ENSP00000379576
ENST00000396280
H7BYP1 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1556 aa
177.8 kDa
No 7
TRPM3-014
ENSP00000350140
ENST00000357533
A2A3F7 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1711 aa
195.3 kDa
No 7
TRPM3-015
ENSP00000350791
ENST00000358082
A2A3F4 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1569 aa
179.1 kDa
No 7
TRPM3-016
ENSP00000386127
ENST00000408909
G5E9G1 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1566 aa
178.9 kDa
No 7
TRPM3-201
ENSP00000354066
ENST00000360823
A2A3F4 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1569 aa
179.1 kDa
No 7
TRPM3-202
ENSP00000366309
ENST00000377105
G5E9G1 [Direct mapping]
Transient receptor potential cation channel subfamily M member 3; Transient receptor potential cation channel, subfamily M, member 3, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005227 [calcium activated cation channel activity]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016048 [detection of temperature stimulus]
GO:0050951 [sensory perception of temperature stimulus]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
1566 aa
178.9 kDa
No 7

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