Expression of POLR2F in cancer - Summary

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	POLR2F
Gene descriptionⁱ Gene description according to HGNC.	Polymerase (RNA) II (DNA directed) polypeptide F
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Predicted intracellular proteins RNA polymerase related proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 2 antibodies. HPA000827 , CAB009882
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

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RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA000827	CAB009882

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	POLR2F (HGNC Symbol)
Synonyms	HRBP14.4, RPB6
Description	Polymerase (RNA) II (DNA directed) polypeptide F (HGNC Symbol)
Entrez gene summary	This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37952607 - 38041915
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100142 (version 83.38)
Entrez gene	5435
UniProt	P61218 (UniProt - Evidence at protein level)
neXtProt	NX_P61218
Antibodypedia	POLR2F antibodies

PROTEIN BROWSERⁱ

POLR2F-001	POLR2F-002	POLR2F-004	POLR2F-006	POLR2F-007	POLR2F-009	POLR2F-010	POLR2F-011	POLR2F-012	POLR2F-013

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR2F-001 ENSP00000403852 ENST00000442738	P61218 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005730 [nucleolus] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0006383 [transcription from RNA polymerase III promoter] GO:0006385 [transcription elongation from RNA polymerase III promoter] GO:0006386 [termination of RNA polymerase III transcription] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0031047 [gene silencing by RNA] GO:0032481 [positive regulation of type I interferon production] GO:0034587 [piRNA metabolic process] GO:0035019 [somatic stem cell population maintenance] GO:0040029 [regulation of gene expression, epigenetic] GO:0045087 [innate immune response] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0050434 [positive regulation of viral transcription] Show all	127 aa 14.5 kDa	No	0
POLR2F-002 ENSP00000475257 ENST00000460648	U3KPV3 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	74 aa 8.1 kDa	No	0
POLR2F-004 ENSP00000475342 ENST00000488684	U3KQQ7 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	76 aa 8.4 kDa	No	0
POLR2F-006 ENSP00000475343 ENST00000492213	U3KPY1 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005634 [nucleus] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	112 aa 12.7 kDa	No	0
POLR2F-007 ENSP00000475707 ENST00000470701	U3KQB0 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005634 [nucleus] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005730 [nucleolus] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	122 aa 13.9 kDa	No	0
POLR2F-009 ENSP00000385725 ENST00000407936	B0QYL9 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	158 aa 17.6 kDa	No	0
POLR2F-010 ENSP00000384112 ENST00000405557	B0QYL8 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	126 aa 14.2 kDa	No	0
POLR2F-011 ENSP00000332130 ENST00000333418	H0Y2U7 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	145 aa 15.1 kDa	No	0
POLR2F-012 ENSP00000389307 ENST00000427034	H0Y439 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	93 aa 9.7 kDa	No	0
POLR2F-013 ENSP00000476187 ENST00000606538	U3KQS8 [Direct mapping] DNA-directed RNA polymerases I, II, and III subunit RPABC2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001054 [RNA polymerase I activity] GO:0001055 [RNA polymerase II activity] GO:0001056 [RNA polymerase III activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005666 [DNA-directed RNA polymerase III complex] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006383 [transcription from RNA polymerase III promoter] Show all	98 aa 11.1 kDa	No	0