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Strong luminal membranous staining was observed in papillary adenocarcinomas of thyroid. Few cases of prostate cancers along with a rare case of seminoma showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
APOBEC3H (HGNC Symbol)
Synonyms
ARP10
Description
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]