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Moderate to strong cytoplasmic immuoreactivity was observed in basal cell carcinoma, a majority of melanomas, colorectal, gastric, testicular and ovarian cancers as well as a few cases in most other cancers. Cancers in general were negative.
GENE INFORMATION
Gene name
PYGB
Synonyms
Description
Phosphorylase, glycogen; brain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]
P11216 [Direct mapping] Glycogen phosphorylase, brain form
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)