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One case of squamous cell carcinoma of cervix showed strong cytoplasmic and membrane positivity. A few basal and squamous cell carcinomas were weakly stained. Remaining malignant cells were mainly negative.
GENE INFORMATION
Gene name
PROCR (HGNC Symbol)
Synonyms
CCD41, CD201, EPCR
Description
Protein C receptor, endothelial (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]