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Tumors predominantly displayed moderate to strong nuclear and cytoplasmic staining. A majority of renal, lung, ovarian and endometrial cancers were weakly stained or negative.
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]