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Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most malignant tissues showed moderate cytoplasmic immunoreactivity with additional nuclear positivity in several cases. Papillary adenocarcinomas of thyroid, several colorectal cancers, hepatocellular carcinomas along with occasional seminomas and pancreatic cancers exhibited strong immunoreactivity. Several malignant gliomas and lymphomas were weakly stained or negative.
Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]