We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of cancers showed moderate immunoreactivity. Strong positivity was seen in thyroid cancers and several cases of liver, urothelial and ovarian cancers. Cervical and skin cancers were mainly negative or weakly stained.
GENE INFORMATION
Gene name
CHN2 (HGNC Symbol)
Synonyms
ARHGAP3, RhoGAP3
Description
Chimerin 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]