Testicular cancers and a majority of colorectal and endometrial cancers showed strong cytoplasmic immunoreactivity. Most other malignant cells were moderately stained.
GARS (HGNC Symbol)
CMT2D, DSMAV, GlyRS, SMAD1
Glycyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary
This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Enzymes ENZYME proteins Ligase Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)