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GARS

GENERAL INFORMATION

Gene name

 GARS

Gene description

 Glycyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA017896 , HPA019097
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable), liver cancer (unfavourable), breast cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Liver cancer p<0.001
Breast cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017896
HPA019097

GENE INFORMATION

Gene name

 GARS (HGNC Symbol)

Synonyms

 CMT2D, DSMAV, GlyRS, SMAD1

Description

 Glycyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 7

Cytoband

 p14.3

Chromosome location (bp)

 30594681 - 30634033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106105 (version 83.38)

Entrez gene

 2617

UniProt

 P41250 (UniProt - Evidence at protein level)

neXtProt

 NX_P41250

Antibodypedia

 GARS antibodies

PROTEIN BROWSER
GARS-001
GARS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GARS-001
ENSP00000373918
ENST00000389266
P41250 [Direct mapping]
Glycine--tRNA ligase
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Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004820 [glycine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006426 [glycyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0015966 [diadenosine tetraphosphate biosynthetic process]
GO:0030141 [secretory granule]
GO:0030424 [axon]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
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 739 aa
83.2 kDa 		Yes 0
GARS-201
ENSP00000485931
ENST00000627489
F8WCK4 [Direct mapping]
Glycine--tRNA ligase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006426 [glycyl-tRNA aminoacylation]
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 79 aa
8.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.