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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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GARS
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

GARS

Gene description

Glycyl-tRNA synthetase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

Supported based on 2 antibodies.
HPA017896 , HPA019097
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable), liver cancer (unfavourable), breast cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Liver cancer p<0.001
Breast cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017896
HPA019097

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues displayed strong cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Testicular cancers and a majority of colorectal and endometrial cancers showed strong cytoplasmic immunoreactivity. Most other malignant cells were moderately stained.

GENE INFORMATION

Gene name

GARS (HGNC Symbol)

Synonyms

CMT2D, DSMAV, GlyRS, SMAD1

Description

Glycyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

30594681 - 30634033

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106105 (version 83.38)

Entrez gene

2617

UniProt

P41250 (UniProt - Evidence at protein level)

neXtProt

NX_P41250

Antibodypedia

GARS antibodies

PROTEIN BROWSER

GARS-001
GARS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GARS-001
ENSP00000373918
ENST00000389266
P41250 [Direct mapping]
Glycine--tRNA ligase
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Enzymes
   ENZYME proteins
   Ligase
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004820 [glycine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006426 [glycyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0015966 [diadenosine tetraphosphate biosynthetic process]
GO:0030141 [secretory granule]
GO:0030424 [axon]
GO:0046983 [protein dimerization activity]
GO:0070062 [extracellular exosome]
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739 aa
83.2 kDa
Yes 0
GARS-201
ENSP00000485931
ENST00000627489
F8WCK4 [Direct mapping]
Glycine--tRNA ligase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006426 [glycyl-tRNA aminoacylation]
Show all
79 aa
8.4 kDa
Yes 0

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