Several cases of colorectal and ovarian cancers showed moderate cytoplasmic positivity with additional membranous staining in a large subset of cases. Most other cancers were weakly stained or negative.
Most cancer tissues displayed weak to moderate nuclear immunoreactivity. Strong positivity was observed in a few gliomas, lymphomas and urothelial cancers.
STK38 (HGNC Symbol)
Serine/threonine kinase 38 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]