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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STK38
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STK38

Gene description

Serine/threonine kinase 38

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Pending external verification. Caution, targets protein from more than one gene.

Reliability score

Uncertain based on 2 antibodies.
HPA038623 , CAB004673
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PROGNOSTIC SUMMARY

Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA038623
CAB004673

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of colorectal and ovarian cancers showed moderate cytoplasmic positivity with additional membranous staining in a large subset of cases. Most other cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed weak to moderate nuclear immunoreactivity. Strong positivity was observed in a few gliomas, lymphomas and urothelial cancers.

GENE INFORMATION

Gene name

STK38 (HGNC Symbol)

Synonyms

NDR

Description

Serine/threonine kinase 38 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

36493892 - 36547470

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112079 (version 83.38)

Entrez gene

11329

UniProt

Q15208 (UniProt - Evidence at protein level)

neXtProt

NX_Q15208

Antibodypedia

STK38 antibodies

PROTEIN BROWSER

STK38-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK38-001
ENSP00000229812
ENST00000229812
Q15208 [Direct mapping]
Serine/threonine-protein kinase 38
A0A024RD18 [Target identity:100%; Query identity:100%]
Serine/threonine kinase 38, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0070688 [MLL5-L complex]
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465 aa
54.2 kDa
No 0

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