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STK38

GENERAL INFORMATION

Gene name

 STK38

Gene description

 Serine/threonine kinase 38

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 2 antibodies.
HPA038623 , CAB004673
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA038623
CAB004673

GENE INFORMATION

Gene name

 STK38 (HGNC Symbol)

Synonyms

 NDR

Description

 Serine/threonine kinase 38 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 36493892 - 36547470

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112079 (version 83.38)

Entrez gene

 11329

UniProt

 Q15208 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15208

Antibodypedia

 STK38 antibodies

PROTEIN BROWSER
STK38-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STK38-001
ENSP00000229812
ENST00000229812
Q15208 [Direct mapping]
Serine/threonine-protein kinase 38
A0A024RD18 [Target identity:100%; Query identity:100%]
Serine/threonine kinase 38, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0070688 [MLL5-L complex]
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 465 aa
54.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.