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GHR

GENERAL INFORMATION

Gene namei

 GHR

Gene descriptioni

 Growth hormone receptor

Protein classi

 Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localizationi

 Membrane

Number of transcriptsi

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (T-47d)
HPA (normal tissue):Group enriched (adipose tissue, liver)

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 Highly abundant cytoplasmic expression mainly in hepatocytes and membranous expression in renal tubular cells. Also expressed in the cell membrane in most glandular epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Antibody staining mainly consistent with RNA expression data.

Reliability scorei

 Supported based on 1 antibody.
HPA045339
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PROGNOSTIC SUMMARYi
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Mixed

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
HPA045339

GENE INFORMATIONi

Gene name

 GHR (HGNC Symbol)

Synonyms

 GHBP

Description

 Growth hormone receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

Chromosome location (bp)

 42423777 - 42721878

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112964 (version 83.38)

Entrez gene

 2690

UniProt

 P10912 (UniProt - Evidence at protein level)

neXtProt

 NX_P10912

Antibodypedia

 GHR antibodies

PROTEIN BROWSERi
GHR-001
GHR-201
GHR-202
GHR-203
GHR-204
GHR-205
GHR-206
GHR-207
GHR-208

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GHR-001
ENSP00000230882
ENST00000230882
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-201
ENSP00000350335
ENST00000357703
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 616 aa
69.2 kDa 		Yes 1
GHR-202
ENSP00000442206
ENST00000537449
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-203
ENSP00000478332
ENST00000612382
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-204
ENSP00000479846
ENST00000612626
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-205
ENSP00000478291
ENST00000615111
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-206
ENSP00000482373
ENST00000618088
P10912 [Direct mapping]
Growth hormone receptor Growth hormone-binding protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0000255 [allantoin metabolic process]
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006101 [citrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006105 [succinate metabolic process]
GO:0006107 [oxaloacetate metabolic process]
GO:0006549 [isoleucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0006600 [creatine metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006897 [endocytosis]
GO:0007259 [JAK-STAT cascade]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019530 [taurine metabolic process]
GO:0019838 [growth factor binding]
GO:0019901 [protein kinase binding]
GO:0031623 [receptor internalization]
GO:0032355 [response to estradiol]
GO:0032870 [cellular response to hormone stimulus]
GO:0040014 [regulation of multicellular organism growth]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042803 [protein homodimerization activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043235 [receptor complex]
GO:0044236 [multicellular organismal metabolic process]
GO:0046449 [creatinine metabolic process]
GO:0046898 [response to cycloheximide]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070064 [proline-rich region binding]
GO:0070195 [growth hormone receptor complex]
Show all
 638 aa
71.5 kDa 		Yes 1
GHR-207
ENSP00000483403
ENST00000620156
A0A087X0H5 [Direct mapping]
Growth hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004896 [cytokine receptor activity]
GO:0004903 [growth hormone receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0007259 [JAK-STAT cascade]
GO:0009725 [response to hormone]
GO:0009755 [hormone-mediated signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019898 [extrinsic component of membrane]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0032094 [response to food]
GO:0032869 [cellular response to insulin stimulus]
GO:0034097 [response to cytokine]
GO:0042169 [SH2 domain binding]
GO:0042976 [activation of Janus kinase activity]
GO:0042977 [activation of JAK2 kinase activity]
GO:0043025 [neuronal cell body]
GO:0043278 [response to morphine]
GO:0043434 [response to peptide hormone]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0051384 [response to glucocorticoid]
GO:0060351 [cartilage development involved in endochondral bone morphogenesis]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0070555 [response to interleukin-1]
GO:1901215 [negative regulation of neuron death]
Show all
 645 aa
72.2 kDa 		Yes 1
GHR-208
ENSP00000483926
ENST00000622294
A0A087X162 [Direct mapping]
Growth hormone receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 295 aa
34 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.