Expression of BCL6 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	BCL6
Gene descriptionⁱ Gene description according to HGNC.	B-cell CLL/lymphoma 6
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, U-698)
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Nuclear expression, mainly in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly not consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 2 antibodies. HPA004899 , CAB000307
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

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RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA004899	CAB000307

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	BCL6 (HGNC Symbol)
Synonyms	BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Description	B-cell CLL/lymphoma 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	187721377 - 187745727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113916 (version 83.38)
Entrez gene	604
UniProt	P41182 (UniProt - Evidence at protein level)
neXtProt	NX_P41182
Antibodypedia	BCL6 antibodies

PROTEIN BROWSERⁱ

BCL6-001	BCL6-004	BCL6-007	BCL6-008	BCL6-010	BCL6-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL6-001 ENSP00000384371 ENST00000406870	P41182 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Show all	GO:0000060 [protein import into nucleus, translocation] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000902 [cell morphogenesis] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001161 [intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0002467 [germinal center formation] GO:0002634 [regulation of germinal center formation] GO:0002829 [negative regulation of type 2 immune response] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005657 [replication fork] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007266 [Rho protein signal transduction] GO:0007283 [spermatogenesis] GO:0008104 [protein localization] GO:0008285 [negative regulation of cell proliferation] GO:0030036 [actin cytoskeleton organization] GO:0030183 [B cell differentiation] GO:0030308 [negative regulation of cell growth] GO:0030890 [positive regulation of B cell proliferation] GO:0031065 [positive regulation of histone deacetylation] GO:0031490 [chromatin DNA binding] GO:0032764 [negative regulation of mast cell cytokine production] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043380 [regulation of memory T cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045596 [negative regulation of cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048294 [negative regulation of isotype switching to IgE isotypes] GO:0048821 [erythrocyte development] GO:0050727 [regulation of inflammatory response] GO:0050776 [regulation of immune response] GO:0051272 [positive regulation of cellular component movement] GO:2000773 [negative regulation of cellular senescence] Show all	706 aa 78.8 kDa	No	0
BCL6-004 ENSP00000232014 ENST00000232014	P41182 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Show all	GO:0000060 [protein import into nucleus, translocation] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002634 [regulation of germinal center formation] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005657 [replication fork] GO:0006351 [transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0030308 [negative regulation of cell growth] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0050727 [regulation of inflammatory response] GO:0050776 [regulation of immune response] Show all	706 aa 78.8 kDa	No	0
BCL6-007 ENSP00000414455 ENST00000438077	C9JL16 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0045595 [regulation of cell differentiation] GO:0050727 [regulation of inflammatory response] Show all	104 aa 11.8 kDa	No	0
BCL6-008 ENSP00000415574 ENST00000430339	C9JCS5 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0005515 [protein binding] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0045595 [regulation of cell differentiation] GO:0050727 [regulation of inflammatory response] Show all	122 aa 13.9 kDa	No	0
BCL6-010 ENSP00000413122 ENST00000450123	P41182 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Show all	GO:0000060 [protein import into nucleus, translocation] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002634 [regulation of germinal center formation] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005657 [replication fork] GO:0006351 [transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0030308 [negative regulation of cell growth] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0050727 [regulation of inflammatory response] GO:0050776 [regulation of immune response] Show all	650 aa 72.4 kDa	No	0
BCL6-201 ENSP00000479784 ENST00000621333	P41182 [Direct mapping] B-cell lymphoma 6 protein Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Show all	GO:0000060 [protein import into nucleus, translocation] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002634 [regulation of germinal center formation] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005657 [replication fork] GO:0006351 [transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0030308 [negative regulation of cell growth] GO:0042092 [type 2 immune response] GO:0042127 [regulation of cell proliferation] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045595 [regulation of cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0050727 [regulation of inflammatory response] GO:0050776 [regulation of immune response] Show all	650 aa 72.4 kDa	No	0