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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CD86
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

CD86

Gene descriptioni

Gene description according to HGNC.

CD86 molecule

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

CD markers
FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Membrane,Secreted

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Tissue enhanced (appendix)

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic expression in several tissues including, lymphoid tissue.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Uncertain based on 1 antibody.
CAB004319
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

CAB004319

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

A majority of cancer tissues displayed moderate cytoplasmic positivity.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CD86 (HGNC Symbol)

Synonyms

B7-2, B7.2, CD28LG2

Description

CD86 molecule (HGNC Symbol)

Entrez gene summary

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Chromosome

3

Cytoband

q13.33

Chromosome location (bp)

122055366 - 122121139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114013 (version 83.38)

Entrez gene

942

UniProt

P42081 (UniProt - Evidence at protein level)

neXtProt

NX_P42081

Antibodypedia

CD86 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

CD86-001
CD86-002
CD86-003
CD86-004
CD86-005
CD86-007
CD86-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD86-001
ENSP00000332049
ENST00000330540
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001878 [response to yeast]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002309 [T cell proliferation involved in immune response]
GO:0002668 [negative regulation of T cell anergy]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0032496 [response to lipopolysaccharide]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034341 [response to interferon-gamma]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042493 [response to drug]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071248 [cellular response to metal ion]
GO:0071345 [cellular response to cytokine stimulus]
Show all
329 aa
37.7 kDa
Yes 1
CD86-002
ENSP00000377248
ENST00000393627
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
323 aa
37 kDa
Yes 1
CD86-003
ENSP00000418988
ENST00000469710
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
247 aa
28.4 kDa
No 1
CD86-004
ENSP00000420230
ENST00000493101
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
217 aa
24.8 kDa
Yes 1
CD86-005
ENSP00000417195
ENST00000478741
H7C4F8 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
277 aa
31.4 kDa
Yes 0
CD86-007
ENSP00000419116
ENST00000482356
C9JXS1 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
167 aa
19 kDa
Yes 0
CD86-201
ENSP00000264468
ENST00000264468
P42081 [Direct mapping]
T-lymphocyte activation antigen CD86
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016021 [integral component of membrane]
GO:0031295 [T cell costimulation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0043017 [positive regulation of lymphotoxin A biosynthetic process]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045404 [positive regulation of interleukin-4 biosynthetic process]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0070062 [extracellular exosome]
Show all
275 aa
31.3 kDa
Yes 0

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