Expression of CD86 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	CD86
Gene descriptionⁱ Gene description according to HGNC.	CD86 molecule
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	CD markers FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Tissue enhanced (appendix)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Cytoplasmic expression in several tissues including, lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Uncertain based on 1 antibody. CAB004319
	SHOW MORE

PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

CAB004319

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CD86 (HGNC Symbol)
Synonyms	B7-2, B7.2, CD28LG2
Description	CD86 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Chromosome	3
Cytoband	q13.33
Chromosome location (bp)	122055366 - 122121139
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114013 (version 83.38)
Entrez gene	942
UniProt	P42081 (UniProt - Evidence at protein level)
neXtProt	NX_P42081
Antibodypedia	CD86 antibodies

PROTEIN BROWSERⁱ

CD86-001	CD86-002	CD86-003	CD86-004	CD86-005	CD86-007	CD86-201

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD86-001 ENSP00000332049 ENST00000330540	P42081 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001878 [response to yeast] GO:0002224 [toll-like receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002309 [T cell proliferation involved in immune response] GO:0002668 [negative regulation of T cell anergy] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007568 [aging] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0032496 [response to lipopolysaccharide] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034341 [response to interferon-gamma] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042102 [positive regulation of T cell proliferation] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042493 [response to drug] GO:0043011 [myeloid dendritic cell differentiation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051607 [defense response to virus] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide] GO:0071248 [cellular response to metal ion] GO:0071345 [cellular response to cytokine stimulus] Show all	329 aa 37.7 kDa	Yes	1
CD86-002 ENSP00000377248 ENST00000393627	P42081 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular exosome] Show all	323 aa 37 kDa	Yes	1
CD86-003 ENSP00000418988 ENST00000469710	P42081 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular exosome] Show all	247 aa 28.4 kDa	No	1
CD86-004 ENSP00000420230 ENST00000493101	P42081 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular exosome] Show all	217 aa 24.8 kDa	Yes	1
CD86-005 ENSP00000417195 ENST00000478741	H7C4F8 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	277 aa 31.4 kDa	Yes	0
CD86-007 ENSP00000419116 ENST00000482356	C9JXS1 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	167 aa 19 kDa	Yes	0
CD86-201 ENSP00000264468 ENST00000264468	P42081 [Direct mapping] T-lymphocyte activation antigen CD86 Show all	CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002250 [adaptive immune response] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0043017 [positive regulation of lymphotoxin A biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045404 [positive regulation of interleukin-4 biosynthetic process] GO:0045630 [positive regulation of T-helper 2 cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046718 [viral entry into host cell] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0070062 [extracellular exosome] Show all	275 aa 31.3 kDa	Yes	0