We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Several cases of urothelial and endometrial cancers exhibited moderate to strong cytoplasmic and membranous immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
Several malignant carcinoids, urothelial, colorectal and endometrial cancers along with a few squamous cell carcinomas and gastric cancers displayed moderate to strong cytoplasmic immunoreactivity with additional membranous staining in a few cases. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
UPK1B (HGNC Symbol)
Synonyms
TSPAN20, UPK1
Description
Uroplakin 1B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]