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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACVR1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

ACVR1

Gene descriptioni

Gene description according to HGNC.

Activin A receptor, type I

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Membrane,Secreted

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic expression in most tissues, including smooth muscle positivity.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Approved based on 1 antibody.
HPA007505
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA007505

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Cancer tissues showed weak cytoplasmic immunoreactivity. Several melanomas, breast, prostate and testicular cancers were moderately stained.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ACVR1 (HGNC Symbol)

Synonyms

ACVR1A, ACVRLK2, ALK2, SKR1

Description

Activin A receptor, type I (HGNC Symbol)

Entrez gene summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q24.1

Chromosome location (bp)

157736444 - 157875862

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115170 (version 83.38)

Entrez gene

90

UniProt

Q04771 (UniProt - Evidence at protein level)

neXtProt

NX_Q04771

Antibodypedia

ACVR1 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

ACVR1-001
ACVR1-002
ACVR1-003
ACVR1-004
ACVR1-005
ACVR1-006
ACVR1-007
ACVR1-009
ACVR1-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1-001
ENSP00000263640
ENST00000263640
Q04771 [Direct mapping]
Activin receptor type-1
D3DPA4 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0001569 [patterning of blood vessels]
GO:0001701 [in utero embryonic development]
GO:0001702 [gastrulation with mouth forming second]
GO:0001707 [mesoderm formation]
GO:0001755 [neural crest cell migration]
GO:0002526 [acute inflammatory response]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003183 [mitral valve morphogenesis]
GO:0003289 [atrial septum primum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005025 [transforming growth factor beta receptor activity, type I]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007281 [germ cell development]
GO:0007368 [determination of left/right symmetry]
GO:0007369 [gastrulation]
GO:0007498 [mesoderm development]
GO:0007507 [heart development]
GO:0009968 [negative regulation of signal transduction]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017046 [peptide hormone binding]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030278 [regulation of ossification]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045177 [apical part of cell]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0050431 [transforming growth factor beta binding]
GO:0051145 [smooth muscle cell differentiation]
GO:0060037 [pharyngeal system development]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061445 [endocardial cushion cell fate commitment]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
509 aa
57.2 kDa
Yes 1
ACVR1-002
ENSP00000440091
ENST00000539637
F5GY91 [Direct mapping]
Activin receptor type-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
73 aa
8.1 kDa
Yes 0
ACVR1-003
ENSP00000387273
ENST00000409283
Q04771 [Direct mapping]
Activin receptor type-1
D3DPA4 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003183 [mitral valve morphogenesis]
GO:0003289 [atrial septum primum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017046 [peptide hormone binding]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030278 [regulation of ossification]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0050431 [transforming growth factor beta binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061445 [endocardial cushion cell fate commitment]
GO:0071773 [cellular response to BMP stimulus]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
509 aa
57.2 kDa
Yes 1
ACVR1-004
ENSP00000400767
ENST00000424669
C9J1R3 [Direct mapping]
Activin receptor type-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
71 aa
7.8 kDa
Yes 0
ACVR1-005
ENSP00000401189
ENST00000440523
C9JHJ7 [Direct mapping]
Activin receptor type-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
87 aa
9.6 kDa
Yes 0
ACVR1-006
ENSP00000399322
ENST00000413751
C9JW28 [Direct mapping]
Activin receptor type-1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
21 aa
2.2 kDa
No 0
ACVR1-007
ENSP00000403006
ENST00000412025
C9JHJ7 [Direct mapping]
Activin receptor type-1
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
87 aa
9.6 kDa
Yes 0
ACVR1-009
ENSP00000387127
ENST00000410057
Q04771 [Direct mapping]
Activin receptor type-1
D3DPA4 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003183 [mitral valve morphogenesis]
GO:0003289 [atrial septum primum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017046 [peptide hormone binding]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030278 [regulation of ossification]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0050431 [transforming growth factor beta binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061445 [endocardial cushion cell fate commitment]
GO:0071773 [cellular response to BMP stimulus]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
509 aa
57.2 kDa
Yes 1
ACVR1-201
ENSP00000405004
ENST00000434821
Q04771 [Direct mapping]
Activin receptor type-1
D3DPA4 [Target identity:100%; Query identity:100%]
Serine/threonine-protein kinase receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003183 [mitral valve morphogenesis]
GO:0003289 [atrial septum primum morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017046 [peptide hormone binding]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030278 [regulation of ossification]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0050431 [transforming growth factor beta binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060923 [cardiac muscle cell fate commitment]
GO:0061445 [endocardial cushion cell fate commitment]
GO:0071773 [cellular response to BMP stimulus]
GO:2000017 [positive regulation of determination of dorsal identity]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
509 aa
57.2 kDa
Yes 1

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