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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FARSB
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FARSB

Gene description

Phenylalanyl-tRNA synthetase, beta subunit

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Most abundant in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 3 antibodies.
HPA036677 , HPA036678 , HPA061398
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036677
HPA036678
HPA061398

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several colorectal, breast, prostate, stomach, pancreas, testis, liver and lung cancers showed moderate cytoplasmic positivity. Rare cases of breast, pancreas, stomach and testis cancers showed strong cytoplasmic staining. Other cancer tissues were in general weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic immunoreactivity was observed in colorectal, breast, ovarian and testicular cancers. Remaining tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Several seminomas and few endometrial cancers displayed strong immunoreactivity. Several lymphomas were negative.

GENE INFORMATION

Gene name

FARSB (HGNC Symbol)

Synonyms

FARSLB, FRSB, PheHB

Description

Phenylalanyl-tRNA synthetase, beta subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

2

Cytoband

q36.1

Chromosome location (bp)

222570536 - 222656337

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116120 (version 83.38)

Entrez gene

10056

UniProt

Q9NSD9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NSD9

Antibodypedia

FARSB antibodies

PROTEIN BROWSER

FARSB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FARSB-001
ENSP00000281828
ENST00000281828
Q9NSD9 [Direct mapping]
Phenylalanine--tRNA ligase beta subunit
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003723 [RNA binding]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
Show all
589 aa
66.1 kDa
No 0

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