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FARSB

GENERAL INFORMATION

Gene name

 FARSB

Gene description

 Phenylalanyl-tRNA synthetase, beta subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Most abundant in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA036677 , HPA036678 , HPA061398
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036677
HPA036678
HPA061398

GENE INFORMATION

Gene name

 FARSB (HGNC Symbol)

Synonyms

 FARSLB, FRSB, PheHB

Description

 Phenylalanyl-tRNA synthetase, beta subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 222570536 - 222656337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116120 (version 83.38)

Entrez gene

 10056

UniProt

 Q9NSD9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSD9

Antibodypedia

 FARSB antibodies

PROTEIN BROWSER
FARSB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FARSB-001
ENSP00000281828
ENST00000281828
Q9NSD9 [Direct mapping]
Phenylalanine--tRNA ligase beta subunit
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003723 [RNA binding]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
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 589 aa
66.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.