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A majority of colorectal, ovarian, pancreatic and liver cancers showed moderate cytoplasmic positivity. Several cases of endometrial, testicular and urothelial cancers were also moderately stained. Remaining malignancies were weakly stained or negative.
GENE INFORMATION
Gene name
SCP2
Synonyms
Description
Sterol carrier protein 2 (HGNC Symbol)
Entrez gene summary
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]
P22307 [Direct mapping] Non-specific lipid-transfer protein
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P22307 [Direct mapping] Non-specific lipid-transfer protein
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)