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Several hepatocellular cancers in the liver were strongly stained and several melanoma and prostate cancers showed moderate positivity. Most remaining cancer tissues were weakly stained or negative.
Most liver cancers and several gastric cancers showed moderate to strong cytoplasmic staining. Moderate cytoplasmic staining was observed in several ovarian and urotheial cancers as well as several squamous cell carcinomas.
The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]