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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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VAMP8
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

VAMP8

Gene description

Vesicle-associated membrane protein 8

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NB-4)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 3 antibodies.
HPA006882 , CAB037132 , CAB037147
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in thyroid cancer (favourable) and urothelial cancer (favourable).
Thyroid cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA006882
CAB037132
CAB037147

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer cells displayed moderate to strong cytoplasmic immunoreactivity, in some cases accentuated to the plasma membrane. Strongest staining was found in prostate and liver cancers and in lymphomas. Several cases of skin cancers and gliomas were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed moderate to strong cytoplasmic positivity, with additional luminal membranous staining in many cases. Gliomas were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong membranous and cytoplasmic staining.

GENE INFORMATION

Gene name

VAMP8 (HGNC Symbol)

Synonyms

EDB

Description

Vesicle-associated membrane protein 8 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

Chromosome

2

Cytoband

p11.2

Chromosome location (bp)

85561562 - 85582031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118640 (version 83.38)

Entrez gene

8673

UniProt

Q9BV40 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BV40

Antibodypedia

VAMP8 antibodies

PROTEIN BROWSER

VAMP8-001
VAMP8-002
VAMP8-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAMP8-001
ENSP00000263864
ENST00000263864
Q9BV40 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006906 [vesicle fusion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019869 [chloride channel inhibitor activity]
GO:0030667 [secretory granule membrane]
GO:0031201 [SNARE complex]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0035577 [azurophil granule membrane]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070254 [mucus secretion]
GO:0097352 [autophagosome maturation]
GO:0098594 [mucin granule]
GO:1903076 [regulation of protein localization to plasma membrane]
GO:1903531 [negative regulation of secretion by cell]
GO:1903595 [positive regulation of histamine secretion by mast cell]
Show all
100 aa
11.4 kDa
No 1
VAMP8-002
ENSP00000407984
ENST00000432071
C9JXZ5 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
74 aa
8.6 kDa
No 1
VAMP8-003
ENSP00000387094
ENST00000409760
B8ZZT4 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
99 aa
11.2 kDa
No 0

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