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Moderate cytoplasmic immunoreactivity was observed in several ductal breast carcinomas as well as fractions of cases in several other cancers. Malignant cells in general were weakly stained or negative.
GENE INFORMATION
Gene name
CENPL (HGNC Symbol)
Synonyms
C1orf155, dJ383J4.3, FLJ31044
Description
Centromere protein L (HGNC Symbol)
Entrez gene summary
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]