Expression of ZNFX1 in cancer - Summary - The Human Protein Atlas

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ZNFX1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNFX1
Gene description	Zinc finger, NFX1-type containing 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA046629
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046629

GENE INFORMATION
Gene name	ZNFX1 (HGNC Symbol)
Synonyms	FLJ11277, KIAA1404
Description	Zinc finger, NFX1-type containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49237946 - 49278426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124201 (version 83.38)
Entrez gene	57169
UniProt	Q9P2E3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P2E3
Antibodypedia	ZNFX1 antibodies

PROTEIN BROWSER

ZNFX1-001	ZNFX1-002	ZNFX1-003	ZNFX1-004	ZNFX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNFX1-001 ENSP00000360817 ENST00000371752	Q9P2E3 [Direct mapping] NFX1-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	1918 aa 220.2 kDa	No	0
ZNFX1-002 ENSP00000360809 ENST00000371744	Q5JXR5 [Direct mapping] NFX1-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	934 aa 107.9 kDa	No	0
ZNFX1-003 ENSP00000413800 ENST00000455070	Q5JXR7 [Direct mapping] NFX1-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		707 aa 81.2 kDa	No	0
ZNFX1-004 ENSP00000360819 ENST00000371754	Q5JXR6 [Direct mapping] NFX1-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	1270 aa 146.2 kDa	No	0
ZNFX1-201 ENSP00000379412 ENST00000396105	Q9P2E3 [Direct mapping] NFX1-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	1918 aa 220.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.