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Rare case of liver, cervical and lung cancers displayed strong cytoplasmic positivity. Moderate staining was observed in occasional cases of liver, pancreas, urothelial, testis, lung, colorectal and breast cancers. Remaining malignant tissues were weakly stained or negative.
GENE INFORMATION
Gene name
NEURL2 (HGNC Symbol)
Synonyms
C20orf163, dJ337O18.6, FLJ30259, Ozz, Ozz-E3
Description
Neuralized E3 ubiquitin protein ligase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]