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A few pancreatic, colorectal, liver, ovarian, endometrial and lung cancers showed weak to moderate cytoplasmic staining. Other malignant tissues were generally negative.
GENE INFORMATION
Gene name
HCST (HGNC Symbol)
Synonyms
DAP10, DKFZP586C1522, KAP10, PIK3AP
Description
Hematopoietic cell signal transducer (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]