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Papillary adenocarcinomas of thyroid along with several squamous cell carcinomas, non-Hodgkins lymphomas, colorectal and gastric cancers as well as a few melanomas, ovarian and endometrial cancers displayed moderate to strong cytoplasmic immunoreactivity. Remaining cancer cells were in general weakly stained or negative.
Cancer cells displayed weak to moderate cytoplasmic and occasional membranous staining. Several cases of gliomas, lymphomas and skin cancers were negative.
GENE INFORMATION
Gene name
OSBPL2 (HGNC Symbol)
Synonyms
DFNA67, KIAA0772, ORP-2
Description
Oxysterol binding protein-like 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]