A few squamous cell carcinomas, melanomas, colorectal, cervical, stomach and pancreatic cancers along with several prostate cancers showed weak to moderate cytoplasmic and/or membranous staining. A single case of stomach cancer showed strong nuclear staining. Remaining cancer tissues were negative.
STK26 (HGNC Symbol)
Serine/threonine protein kinase 26 (HGNC Symbol)
Entrez gene summary
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]