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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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STK26
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

STK26

Gene description

Serine/threonine protein kinase 26

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA059921
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA059921

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few squamous cell carcinomas, melanomas, colorectal, cervical, stomach and pancreatic cancers along with several prostate cancers showed weak to moderate cytoplasmic and/or membranous staining. A single case of stomach cancer showed strong nuclear staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

STK26 (HGNC Symbol)

Synonyms

MASK, MST4

Description

Serine/threonine protein kinase 26 (HGNC Symbol)

Entrez gene summary

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q26.2

Chromosome location (bp)

132023265 - 132075943

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134602 (version 83.38)

Entrez gene

51765

UniProt

Q9P289 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P289

Antibodypedia

STK26 antibodies

PROTEIN BROWSER

STK26-001
STK26-002
STK26-003
STK26-004
STK26-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK26-001
ENSP00000377867
ENST00000394334
Q9P289 [Direct mapping]
Serine/threonine-protein kinase 26
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007346 [regulation of mitotic cell cycle]
GO:0012501 [programmed cell death]
GO:0016324 [apical plasma membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1903205 [regulation of hydrogen peroxide-induced cell death]
Show all
416 aa
46.5 kDa
No 0
STK26-002
ENSP00000346755
ENST00000354719
Q8NBY1 [Direct mapping]
Serine/threonine-protein kinase 26; cDNA FLJ90669 fis, clone PLACE1005519, moderately similar to Homo sapiens STE20-like kinase 3 (mst-3) mRNA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
392 aa
43.9 kDa
No 0
STK26-003
ENSP00000419702
ENST00000496850
Q9P289 [Direct mapping]
Serine/threonine-protein kinase 26
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007346 [regulation of mitotic cell cycle]
GO:0012501 [programmed cell death]
GO:0016324 [apical plasma membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1903205 [regulation of hydrogen peroxide-induced cell death]
Show all
354 aa
39.7 kDa
No 0
STK26-004
ENSP00000418753
ENST00000481105
B4E0Y9 [Direct mapping]
Serine/threonine-protein kinase 26; cDNA FLJ54528, highly similar to Serine/threonine-protein kinase MST4 (EC 2.7.11.1); cDNA, FLJ79036, highly similar to Serine/threonine-protein kinase MST4 (EC 2.7.11.1)
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
438 aa
49.2 kDa
No 0
STK26-005
ENSP00000377868
ENST00000394335
Q9P289 [Direct mapping]
Serine/threonine-protein kinase 26
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007346 [regulation of mitotic cell cycle]
GO:0012501 [programmed cell death]
GO:0016324 [apical plasma membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030033 [microvillus assembly]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1903205 [regulation of hydrogen peroxide-induced cell death]
Show all
339 aa
37.8 kDa
No 0

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The Human Protein Atlas project is funded
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