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Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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FPGS
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FPGS

Gene description

Folylpolyglutamate synthase

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, highly abundant in smooth muscles.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA050488
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

FPGS

Synonyms

Description

Folylpolyglutamate synthase (HGNC Symbol)

Entrez gene summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

127794597 - 127814327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136877 (version 83.38)

Entrez gene

2356

UniProt

Q05932 (UniProt - Evidence at protein level)

neXtProt

NX_Q05932

Antibodypedia

FPGS antibodies

PROTEIN BROWSER

FPGS-001
FPGS-011
FPGS-012
FPGS-017
FPGS-020
FPGS-201
FPGS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FPGS-001
ENSP00000406328
ENST00000423577
Q5JU21 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
194 aa
21.6 kDa
No 0
FPGS-011
ENSP00000362344
ENST00000373247
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0031100 [organ regeneration]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
587 aa
64.6 kDa
Yes 0
FPGS-012
ENSP00000362322
ENST00000373225
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
537 aa
59.2 kDa
No 0
FPGS-017
ENSP00000362325
ENST00000373228
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
375 aa
40.9 kDa
Yes 0
FPGS-020
ENSP00000400007
ENST00000431857
Q5JU20 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
265 aa
29.2 kDa
No 0
FPGS-201
ENSP00000377309
ENST00000393706
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
561 aa
61.6 kDa
Yes 0
FPGS-202
ENSP00000486766
ENST00000630236
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
375 aa
40.9 kDa
Yes 0

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