We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Moderate granular cytoplasmic staining was observed in prostate cancers, several cases of colorectal, breast, endometrial, pancreatic cancers and squamous cell carcinomas showed moderate granular cytoplasmic staining. Remaining cancers were weakly stained or negative.
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]