The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal cells showed moderate to strong cytoplasmic positivity. Cells in CNS mainly negative.
Membranous and cytoplasmic staining was found in a fraction of cells in glandular epithelia, mainly seen in gastro intestinal tract. Most other cells were negative.
Strong cytoplasmic positivity was seen in skeletal muscles while trophoblastic cells showed strong membranous staining. Respiratory epithelia, urothelium, breast, cervical and endometrial glands displayed moderate cytoplasmic and membranous immunoreactivity. Most remaining normal cells were weakly stained or negative.
Weak to moderate cytoplasmic positivity was displayed in respiratory epithelia, intestinal glands, thyroid, cells in seminiferus ducts, cervical glands and skeletal myocytes. Additional or membranous staining was exhibited in squamous epithelial cells, placental trophoblasts and urothelial cells. Renal tubules showed strong cytoplasmic staining. Remaining normal tissues were negative.