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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABL2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

ABL2

Gene descriptioni

Gene description according to HGNC.

ABL proto-oncogene 2, non-receptor tyrosine kinase

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Caution, splice and/or transcript discrepancy exists and external data suggests several subcellular locations.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Uncertain based on 2 antibodies.
HPA001866 , CAB017106
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA001866
CAB017106

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Most cancer tissues displayed moderate nuclear immunoreactivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Weak to moderate nuclear staining often combined with cytoplasmic positivity, was observed in most cancer tissues. Several cases of gliomas displayed strong staining.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ABL2 (HGNC Symbol)

Synonyms

ABLL, ARG

Description

ABL proto-oncogene 2, non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Chromosome

1

Cytoband

q25.2

Chromosome location (bp)

179099327 - 179229684

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143322 (version 83.38)

Entrez gene

27

UniProt

P42684 (UniProt - Evidence at protein level)

neXtProt

NX_P42684

Antibodypedia

ABL2 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

ABL2-001
ABL2-002
ABL2-005
ABL2-006
ABL2-007
ABL2-008
ABL2-009
ABL2-010

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABL2-001
ENSP00000427562
ENST00000502732
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001891 [phagocytic cup]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007015 [actin filament organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0008542 [visual learning]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016322 [neuron remodeling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021587 [cerebellum morphogenesis]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032092 [positive regulation of protein binding]
GO:0034613 [cellular protein localization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035640 [exploration behavior]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048813 [dendrite morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0060020 [Bergmann glial cell differentiation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097062 [dendritic spine maintenance]
GO:1900042 [positive regulation of interleukin-2 secretion]
GO:1902715 [positive regulation of interferon-gamma secretion]
GO:1903053 [regulation of extracellular matrix organization]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
1182 aa
128.3 kDa
No 0
ABL2-002
ENSP00000339209
ENST00000344730
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
1064 aa
116.3 kDa
No 0
ABL2-005
ENSP00000423578
ENST00000512653
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
1167 aa
126.7 kDa
No 0
ABL2-006
ENSP00000426831
ENST00000504405
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
1043 aa
114.2 kDa
No 0
ABL2-007
ENSP00000375897
ENST00000392043
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
542 aa
60.9 kDa
No 0
ABL2-008
ENSP00000356595
ENST00000367623
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
1161 aa
126.2 kDa
No 0
ABL2-009
ENSP00000423413
ENST00000507173
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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1058 aa
115.8 kDa
No 0
ABL2-010
ENSP00000424697
ENST00000511413
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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1079 aa
117.9 kDa
No 0

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