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ABL2

GENERAL INFORMATION

Gene namei

 ABL2

Gene descriptioni

 ABL proto-oncogene 2, non-receptor tyrosine kinase

Protein classi

 Cancer-related genes
Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localizationi

 Intracellular

Number of transcriptsi

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Caution, splice and/or transcript discrepancy exists and external data suggests several subcellular locations.

Reliability scorei

 Uncertain based on 2 antibodies.
HPA001866 , CAB017106
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
HPA001866
CAB017106

GENE INFORMATIONi

Gene name

 ABL2 (HGNC Symbol)

Synonyms

 ABLL, ARG

Description

 ABL proto-oncogene 2, non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Chromosome

 1

Cytoband

 q25.2

Chromosome location (bp)

 179099327 - 179229684

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143322 (version 83.38)

Entrez gene

 27

UniProt

 P42684 (UniProt - Evidence at protein level)

neXtProt

 NX_P42684

Antibodypedia

 ABL2 antibodies

PROTEIN BROWSERi
ABL2-001
ABL2-002
ABL2-005
ABL2-006
ABL2-007
ABL2-008
ABL2-009
ABL2-010

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABL2-001
ENSP00000427562
ENST00000502732
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001891 [phagocytic cup]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007015 [actin filament organization]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0007612 [learning]
GO:0008542 [visual learning]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016322 [neuron remodeling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021587 [cerebellum morphogenesis]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032092 [positive regulation of protein binding]
GO:0034613 [cellular protein localization]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0035640 [exploration behavior]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043197 [dendritic spine]
GO:0045087 [innate immune response]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048813 [dendrite morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0060020 [Bergmann glial cell differentiation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097062 [dendritic spine maintenance]
GO:1900042 [positive regulation of interleukin-2 secretion]
GO:1902715 [positive regulation of interferon-gamma secretion]
GO:1903053 [regulation of extracellular matrix organization]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 1182 aa
128.3 kDa 		No 0
ABL2-002
ENSP00000339209
ENST00000344730
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1064 aa
116.3 kDa 		No 0
ABL2-005
ENSP00000423578
ENST00000512653
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1167 aa
126.7 kDa 		No 0
ABL2-006
ENSP00000426831
ENST00000504405
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1043 aa
114.2 kDa 		No 0
ABL2-007
ENSP00000375897
ENST00000392043
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 542 aa
60.9 kDa 		No 0
ABL2-008
ENSP00000356595
ENST00000367623
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1161 aa
126.2 kDa 		No 0
ABL2-009
ENSP00000423413
ENST00000507173
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1058 aa
115.8 kDa 		No 0
ABL2-010
ENSP00000424697
ENST00000511413
P42684 [Direct mapping]
Abelson tyrosine-protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003785 [actin monomer binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0010506 [regulation of autophagy]
GO:0010863 [positive regulation of phospholipase C activity]
GO:0010976 [positive regulation of neuron projection development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0071300 [cellular response to retinoic acid]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 1079 aa
117.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.