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Term
Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

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Specificity

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

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RP5-862P8.2
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RP5-862P8.2

Gene description

Mitogen-activated protein kinase kinase kinase MLK4

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (pancreas)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in adipose tissues and most glandular cells.

DATA RELIABILITY

Data reliability
description

Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA007636
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pancreas)

GENE INFORMATION

Gene name

RP5-862P8.2

Synonyms

Description

Mitogen-activated protein kinase kinase kinase MLK4 (UniProtKB/Swiss-Prot)

Entrez gene summary

Chromosome

1

Cytoband

q42.2

Chromosome location (bp)

233327768 - 233385148

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143674 (version 83.38)

Entrez gene

84451

UniProt

Q5TCX8 (UniProt - Evidence at protein level)

neXtProt

NX_Q5TCX8

Antibodypedia

RP5-862P8.2 antibodies

PROTEIN BROWSER

RP5-862P8.2-001
RP5-862P8.2-002
RP5-862P8.2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RP5-862P8.2-001
ENSP00000355583
ENST00000366624
Q5TCX8 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLK4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007257 [activation of JUN kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0046777 [protein autophosphorylation]
Show all
1036 aa
114 kDa
No 0
RP5-862P8.2-002
ENSP00000355582
ENST00000366623
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
570 aa
63 kDa
No 0
RP5-862P8.2-003
ENSP00000355581
ENST00000366622
X6R610 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLK4
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
482 aa
52.7 kDa
No 0

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