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RP5-862P8.2

GENERAL INFORMATION

Gene name

 RP5-862P8.2

Gene description

 Mitogen-activated protein kinase kinase kinase MLK4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adipose tissues and most glandular cells.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA007636
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pancreas)

GENE INFORMATION

Gene name

 RP5-862P8.2

Synonyms

Description

 Mitogen-activated protein kinase kinase kinase MLK4 (UniProtKB/Swiss-Prot)

Entrez gene summary

Chromosome

 1

Cytoband

 q42.2

Chromosome location (bp)

 233327768 - 233385148

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143674 (version 83.38)

Entrez gene

 84451

UniProt

 Q5TCX8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5TCX8

Antibodypedia

 RP5-862P8.2 antibodies

PROTEIN BROWSER
RP5-862P8.2-001
RP5-862P8.2-002
RP5-862P8.2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RP5-862P8.2-001
ENSP00000355583
ENST00000366624
Q5TCX8 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLK4
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007257 [activation of JUN kinase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0042803 [protein homodimerization activity]
GO:0046777 [protein autophosphorylation]
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 1036 aa
114 kDa 		No 0
RP5-862P8.2-002
ENSP00000355582
ENST00000366623
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 570 aa
63 kDa 		No 0
RP5-862P8.2-003
ENSP00000355581
ENST00000366622
X6R610 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLK4
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 482 aa
52.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.