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Most cancer cells displayed moderate cytoplasmic and nuclear immunoreactivity. Strong staining was observed in hepatocellular carcinomas along with several malignant melanomas, colorectal, ovarian and pancreatic cancers.
GENE INFORMATION
Gene name
SHPRH (HGNC Symbol)
Synonyms
bA545I5.2, FLJ90837, KIAA2023
Description
SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]