The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Placental trophoblasts showed strong membranous positivity. Moderate cytoplasmic positivity was observed in skeletal muscle. Remaining normal cells were negative.
Moderate cytoplasmic positivity was observed in most normal tissues. Respiratory epithelium, trophoblasts, a fraction of cells in the gastrointestinal tract, exocrine pancreas, squamous epithelia of vagina showed strong cytoplasmic staining. Spleen and most cells in CNS were negative.
Most normal tissue displayed moderate cytoplasmic and membranous positivity. Squamous and glandular epithelium showed mainly strong membranous immunoreactivity. Lymphoid tissue, CNS and muscle tissue were weakly stained or negative.
Renal tubules, heart and skeletal myocytes showed strong cytoplasmic positivity. Placental trophoblastic cells and cells in renal glomeruli exhibited strong membranous immunoreactivity. Other normal tissues were generally negative.
Strong membranous positivity was observed in trophoblastic cells in placenta. Squamous epithelial cells and urothelial cells showed moderate membranous and cytoplasmic staining, while respiratory epithelial cells and ependymal cells in lateral ventricle displayed cytoplasmic immunoreactivity. Remaining cells were weakly stained or negative.