Fields »
ABOUT
HELP
BLOG
NONO

GENERAL INFORMATION

Gene name

 NONO

Gene description

 Non-POU domain containing, octamer-binding

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA054094 , HPA054559 , CAB022069
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054094
HPA054559
CAB022069

GENE INFORMATION

Gene name

 NONO (HGNC Symbol)

Synonyms

 NMT55, NRB54, P54, P54NRB, PPP1R114

Description

 Non-POU domain containing, octamer-binding (HGNC Symbol)

Entrez gene summary

 This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 71283192 - 71301168

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147140 (version 83.38)

Entrez gene

 4841

UniProt

 Q15233 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15233

Antibodypedia

 NONO antibodies

PROTEIN BROWSER
NONO-002
NONO-003
NONO-004
NONO-005
NONO-006
NONO-007
NONO-008
NONO-009
NONO-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NONO-002
ENSP00000276079
ENST00000276079
Q15233 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007623 [circadian rhythm]
GO:0008380 [RNA splicing]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
Show all
 471 aa
54.2 kDa 		No 0
NONO-003
ENSP00000362963
ENST00000373856
Q15233 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007623 [circadian rhythm]
GO:0008380 [RNA splicing]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
Show all
 471 aa
54.2 kDa 		No 0
NONO-004
ENSP00000362947
ENST00000373841
Q15233 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007623 [circadian rhythm]
GO:0008380 [RNA splicing]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
Show all
 471 aa
54.2 kDa 		No 0
NONO-005
ENSP00000410299
ENST00000420903
C9J4X2 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 124 aa
14.5 kDa 		No 0
NONO-006
ENSP00000413350
ENST00000413858
C9JYS8 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 248 aa
29.6 kDa 		No 0
NONO-007
ENSP00000415777
ENST00000450092
C9JJ13 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 66 aa
7.7 kDa 		No 0
NONO-008
ENSP00000406673
ENST00000454976
C9IZL7 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 207 aa
23.7 kDa 		No 0
NONO-009
ENSP00000409773
ENST00000418921
H7C367 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 235 aa
28.2 kDa 		No 0
NONO-201
ENSP00000441364
ENST00000535149
Q15233 [Direct mapping]
Non-POU domain-containing octamer-binding protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Yet undefined DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0007623 [circadian rhythm]
GO:0008380 [RNA splicing]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0042802 [identical protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway]
Show all
 382 aa
43.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.