Expression of ADM in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	ADM
Gene descriptionⁱ Gene description according to HGNC.	Adrenomedullin
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-138 MG)
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Cytoplasmic expression and extracellular positivity in several tissues, including placenta, appendix and esophagus.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Approved based on 1 antibody. CAB016075
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

CAB016075

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ADM (HGNC Symbol)
Synonyms	AM
Description	Adrenomedullin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	10304680 - 10307397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148926 (version 83.38)
Entrez gene	133
UniProt	P35318 (UniProt - Evidence at protein level)
neXtProt	NX_P35318
Antibodypedia	ADM antibodies

PROTEIN BROWSERⁱ

ADM-001	ADM-002	ADM-003	ADM-004	ADM-005	ADM-006	ADM-007	ADM-008

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADM-001 ENSP00000278175 ENST00000278175	P35318 [Direct mapping] ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0002031 [G-protein coupled receptor internalization] GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006171 [cAMP biosynthetic process] GO:0006701 [progesterone biosynthetic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008015 [blood circulation] GO:0019731 [antibacterial humoral response] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031623 [receptor internalization] GO:0045906 [negative regulation of vasoconstriction] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] Show all	185 aa 20.4 kDa	Yes	0
ADM-002 ENSP00000436607 ENST00000528655	P35318 [Direct mapping] ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001843 [neural tube closure] GO:0002026 [regulation of the force of heart contraction] GO:0002031 [G-protein coupled receptor internalization] GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006171 [cAMP biosynthetic process] GO:0006701 [progesterone biosynthetic process] GO:0007165 [signal transduction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007267 [cell-cell signaling] GO:0007507 [heart development] GO:0007565 [female pregnancy] GO:0007568 [aging] GO:0008015 [blood circulation] GO:0008209 [androgen metabolic process] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009409 [response to cold] GO:0009611 [response to wounding] GO:0010033 [response to organic substance] GO:0010460 [positive regulation of heart rate] GO:0019731 [antibacterial humoral response] GO:0019933 [cAMP-mediated signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031100 [organ regeneration] GO:0031102 [neuron projection regeneration] GO:0031623 [receptor internalization] GO:0031700 [adrenomedullin receptor binding] GO:0032496 [response to lipopolysaccharide] GO:0032868 [response to insulin] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042594 [response to starvation] GO:0043065 [positive regulation of apoptotic process] GO:0043116 [negative regulation of vascular permeability] GO:0045766 [positive regulation of angiogenesis] GO:0045906 [negative regulation of vasoconstriction] GO:0045909 [positive regulation of vasodilation] GO:0046879 [hormone secretion] GO:0048589 [developmental growth] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] GO:0051384 [response to glucocorticoid] GO:0055074 [calcium ion homeostasis] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0060712 [spongiotrophoblast layer development] GO:0097084 [vascular smooth muscle cell development] GO:2001214 [positive regulation of vasculogenesis] Show all	185 aa 20.4 kDa	Yes	0
ADM-003 ENSP00000431438 ENST00000534464	E9PL83 [Direct mapping] ADM Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	138 aa 15.1 kDa	No	0
ADM-004 ENSP00000436837 ENST00000530439	E9PQE6 [Direct mapping] ADM Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	117 aa 12.9 kDa	No	0
ADM-005 ENSP00000433062 ENST00000524948	E9PML4 [Direct mapping] ADM Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	83 aa 9.2 kDa	Yes	0
ADM-006 ENSP00000434354 ENST00000526492	E9PQT2 [Direct mapping] ADM Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	139 aa 15.2 kDa	Yes	0
ADM-007 ENSP00000435124 ENST00000525063	P35318 [Direct mapping] ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0002031 [G-protein coupled receptor internalization] GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006171 [cAMP biosynthetic process] GO:0006701 [progesterone biosynthetic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008015 [blood circulation] GO:0019731 [antibacterial humoral response] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031623 [receptor internalization] GO:0045906 [negative regulation of vasoconstriction] GO:0050829 [defense response to Gram-negative bacterium] GO:0050830 [defense response to Gram-positive bacterium] Show all	185 aa 20.4 kDa	Yes	0
ADM-008 ENSP00000434749 ENST00000528544	E9PML4 [Direct mapping] ADM Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	83 aa 9.2 kDa	Yes	0