We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
HMGA2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

HMGA2

Gene descriptioni

Gene description according to HGNC.

High mobility group AT-hook 2

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

Read more

HPA:Mixed
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expressioni

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

External characterization data and paired antibodies with high similarity supports the antibody staining pattern.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Approved based on 2 antibodies.
HPA039076 , CAB017809
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARYi

Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.

RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.

Read more
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEWi

Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.

HPA dataseti

HPA dataset
RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.

RNA tissue category HPA
HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataseti

GTEx dataset
RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.

RNA tissue category GTEx
GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataseti

FANTOM5 dataset
Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.

RNA tissue category FANTOM5
FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

HMGA2 (HGNC Symbol)

Synonyms

BABL, HMGIC, LIPO

Description

High mobility group AT-hook 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

65824131 - 65966295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149948 (version 83.38)

Entrez gene

8091

UniProt

P52926 (UniProt - Evidence at protein level)

neXtProt

NX_P52926

Antibodypedia

HMGA2 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

HMGA2-001
HMGA2-003
HMGA2-005
HMGA2-006
HMGA2-008
HMGA2-011
HMGA2-013

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGA2-001
ENSP00000384026
ENST00000403681
P52926 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000975 [regulatory region DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001047 [core promoter binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002062 [chondrocyte differentiation]
GO:0003131 [mesodermal-endodermal cell signaling]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004677 [DNA-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006284 [base-excision repair]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009615 [response to virus]
GO:0010564 [regulation of cell cycle process]
GO:0010628 [positive regulation of gene expression]
GO:0030261 [chromosome condensation]
GO:0031052 [chromosome breakage]
GO:0031492 [nucleosomal DNA binding]
GO:0031507 [heterochromatin assembly]
GO:0032993 [protein-DNA complex]
GO:0035497 [cAMP response element binding]
GO:0035500 [MH2 domain binding]
GO:0035501 [MH1 domain binding]
GO:0035978 [histone H2A-S139 phosphorylation]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0035987 [endodermal cell differentiation]
GO:0035988 [chondrocyte proliferation]
GO:0040008 [regulation of growth]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045444 [fat cell differentiation]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0048333 [mesodermal cell differentiation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048863 [stem cell differentiation]
GO:0051301 [cell division]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071141 [SMAD protein complex]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0090402 [oncogene-induced cell senescence]
GO:2000036 [regulation of stem cell population maintenance]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000685 [positive regulation of cellular response to X-ray]
GO:2000774 [positive regulation of cellular senescence]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining]
GO:2001038 [regulation of cellular response to drug]
Show all
109 aa
11.8 kDa
No 0
HMGA2-003
ENSP00000437621
ENST00000536545
F5H6H0 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000785 [chromatin]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0010564 [regulation of cell cycle process]
GO:0010628 [positive regulation of gene expression]
GO:0019899 [enzyme binding]
GO:0021846 [cell proliferation in forebrain]
GO:0021983 [pituitary gland development]
GO:0030325 [adrenal gland development]
GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway]
GO:0035019 [somatic stem cell population maintenance]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048712 [negative regulation of astrocyte differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060123 [regulation of growth hormone secretion]
GO:0060612 [adipose tissue development]
GO:0060613 [fat pad development]
GO:0090276 [regulation of peptide hormone secretion]
Show all
147 aa
16.4 kDa
No 0
HMGA2-005
ENSP00000377206
ENST00000393578
P52926 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000975 [regulatory region DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001047 [core promoter binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002062 [chondrocyte differentiation]
GO:0003131 [mesodermal-endodermal cell signaling]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004677 [DNA-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006284 [base-excision repair]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009615 [response to virus]
GO:0010564 [regulation of cell cycle process]
GO:0010628 [positive regulation of gene expression]
GO:0030261 [chromosome condensation]
GO:0031052 [chromosome breakage]
GO:0031492 [nucleosomal DNA binding]
GO:0031507 [heterochromatin assembly]
GO:0032993 [protein-DNA complex]
GO:0035497 [cAMP response element binding]
GO:0035500 [MH2 domain binding]
GO:0035501 [MH1 domain binding]
GO:0035978 [histone H2A-S139 phosphorylation]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0035987 [endodermal cell differentiation]
GO:0035988 [chondrocyte proliferation]
GO:0040008 [regulation of growth]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045444 [fat cell differentiation]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0048333 [mesodermal cell differentiation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048863 [stem cell differentiation]
GO:0051301 [cell division]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071141 [SMAD protein complex]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0090402 [oncogene-induced cell senescence]
GO:2000036 [regulation of stem cell population maintenance]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000685 [positive regulation of cellular response to X-ray]
GO:2000774 [positive regulation of cellular senescence]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining]
GO:2001038 [regulation of cellular response to drug]
Show all
90 aa
9.7 kDa
No 0
HMGA2-006
ENSP00000407306
ENST00000425208
P52926 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000975 [regulatory region DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001047 [core promoter binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002062 [chondrocyte differentiation]
GO:0003131 [mesodermal-endodermal cell signaling]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004677 [DNA-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006284 [base-excision repair]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009615 [response to virus]
GO:0010564 [regulation of cell cycle process]
GO:0010628 [positive regulation of gene expression]
GO:0030261 [chromosome condensation]
GO:0031052 [chromosome breakage]
GO:0031492 [nucleosomal DNA binding]
GO:0031507 [heterochromatin assembly]
GO:0032993 [protein-DNA complex]
GO:0035497 [cAMP response element binding]
GO:0035500 [MH2 domain binding]
GO:0035501 [MH1 domain binding]
GO:0035978 [histone H2A-S139 phosphorylation]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0035987 [endodermal cell differentiation]
GO:0035988 [chondrocyte proliferation]
GO:0040008 [regulation of growth]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045444 [fat cell differentiation]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0048333 [mesodermal cell differentiation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048863 [stem cell differentiation]
GO:0051301 [cell division]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071141 [SMAD protein complex]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0090402 [oncogene-induced cell senescence]
GO:2000036 [regulation of stem cell population maintenance]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000685 [positive regulation of cellular response to X-ray]
GO:2000774 [positive regulation of cellular senescence]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining]
GO:2001038 [regulation of cellular response to drug]
Show all
92 aa
10.1 kDa
No 0
HMGA2-008
ENSP00000346658
ENST00000354636
P52926 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   beta-Sheet binding to DNA
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000228 [nuclear chromosome]
GO:0000975 [regulatory region DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001047 [core promoter binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002062 [chondrocyte differentiation]
GO:0003131 [mesodermal-endodermal cell signaling]
GO:0003677 [DNA binding]
GO:0003680 [AT DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004677 [DNA-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006284 [base-excision repair]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009615 [response to virus]
GO:0010564 [regulation of cell cycle process]
GO:0010628 [positive regulation of gene expression]
GO:0030261 [chromosome condensation]
GO:0031052 [chromosome breakage]
GO:0031492 [nucleosomal DNA binding]
GO:0031507 [heterochromatin assembly]
GO:0032993 [protein-DNA complex]
GO:0035497 [cAMP response element binding]
GO:0035500 [MH2 domain binding]
GO:0035501 [MH1 domain binding]
GO:0035978 [histone H2A-S139 phosphorylation]
GO:0035985 [senescence-associated heterochromatin focus]
GO:0035986 [senescence-associated heterochromatin focus assembly]
GO:0035987 [endodermal cell differentiation]
GO:0035988 [chondrocyte proliferation]
GO:0040008 [regulation of growth]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0045444 [fat cell differentiation]
GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0048333 [mesodermal cell differentiation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048863 [stem cell differentiation]
GO:0051301 [cell division]
GO:0051575 [5'-deoxyribose-5-phosphate lyase activity]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071141 [SMAD protein complex]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0090402 [oncogene-induced cell senescence]
GO:2000036 [regulation of stem cell population maintenance]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000685 [positive regulation of cellular response to X-ray]
GO:2000774 [positive regulation of cellular senescence]
GO:2001022 [positive regulation of response to DNA damage stimulus]
GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining]
GO:2001038 [regulation of cellular response to drug]
Show all
106 aa
11.5 kDa
No 0
HMGA2-011
ENSP00000439317
ENST00000541363
F5H2U8 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
99 aa
10.8 kDa
No 0
HMGA2-013
ENSP00000377205
ENST00000393577
F5H2A4 [Direct mapping]
High mobility group protein HMGI-C
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
118 aa
12.7 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.