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Cell line enhanced (HUVEC TERT2, Karpas-707, SiHa, TIME)
HPA (normal tissue):
Tissue enhanced (placenta)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in most tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most cancer cells displayed moderate cytoplasmic immunoreactivity. Strong positivity was observed in some endometrial, urothelial, pancreatic and stomach cancers.
GENE INFORMATION
Gene name
BMP6 (HGNC Symbol)
Synonyms
VGR, VGR1
Description
Bone morphogenetic protein 6 (HGNC Symbol)
Entrez gene summary
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]