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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABI3BP
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

ABI3BP

Gene descriptioni

Gene description according to HGNC.

ABI family, member 3 (NESH) binding protein

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Secreted

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

21
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (ASC TERT1, TIME)
HPA (normal tissue):Mixed

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic expression in several tissues, including immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Uncertain based on 1 antibody.
HPA044127
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Mixed

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA044127

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Several non Hodgkin's lymphomas showed strong cytoplasmic positivity. Occasional colon, endometrial, lung, rare urothelial, liver and pancreatic cancers showed moderate staining. Remaining cancer tissues were in general weakly stained or negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ABI3BP (HGNC Symbol)

Synonyms

DKFZP586L2024, NESHBP, TARSH

Description

ABI family, member 3 (NESH) binding protein (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q12.2

Chromosome location (bp)

100749156 - 100993515

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154175 (version 83.38)

Entrez gene

25890

UniProt

Q7Z7G0 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z7G0

Antibodypedia

ABI3BP antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
ABI3BP-001
ABI3BP-002
ABI3BP-006
ABI3BP-008
ABI3BP-010
ABI3BP-011
ABI3BP-013
ABI3BP-015
ABI3BP-016
ABI3BP-017
ABI3BP-018
ABI3BP-019
ABI3BP-022
ABI3BP-023
ABI3BP-026
ABI3BP-027
ABI3BP-028
ABI3BP-029
ABI3BP-030
ABI3BP-031
ABI3BP-032
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABI3BP-001
ENSP00000284322
ENST00000284322
Q7Z7G0 [Direct mapping]
Target of Nesh-SH3
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005614 [interstitial matrix]
GO:0005615 [extracellular space]
GO:0008201 [heparin binding]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
Show all
1075 aa
118.6 kDa
Yes 0
ABI3BP-002
ENSP00000420524
ENST00000471714
D3YTG3 [Direct mapping]
Target of Nesh-SH3
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
1777 aa
195.3 kDa
Yes 0
ABI3BP-006
ENSP00000433993
ENST00000495063
Q5JPC9 [Direct mapping]
ABI gene family, member 3 (NESH) binding protein, isoform CRA_d; Putative uncharacterized protein DKFZp667H216; Target of Nesh-SH3
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
1005 aa
110.7 kDa
Yes 0
ABI3BP-008
ENSP00000418817
ENST00000495591
H0Y897 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
1131 aa
124.1 kDa
No 0
ABI3BP-010
ENSP00000418479
ENST00000483129
H7C4X4 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
187 aa
20.2 kDa
No 0
ABI3BP-011
ENSP00000417325
ENST00000459682
H7C4H3 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
84 aa
9.2 kDa
No 0
ABI3BP-013
ENSP00000418063
ENST00000466947
H7C4T1 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
187 aa
20.6 kDa
No 0
ABI3BP-015
ENSP00000418024
ENST00000471901
H7C4S3 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
308 aa
33.7 kDa
No 0
ABI3BP-016
ENSP00000417745
ENST00000478235
H7C4N5 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
187 aa
20.4 kDa
No 0
ABI3BP-017
ENSP00000418800
ENST00000482765
H7C524 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
158 aa
17.2 kDa
No 0
ABI3BP-018
ENSP00000420704
ENST00000497395
H7C5S3 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
189 aa
20.3 kDa
No 0
ABI3BP-019
ENSP00000419029
ENST00000486770
H7C556 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
233 aa
25.4 kDa
No 0
ABI3BP-022
ENSP00000436918
ENST00000530539
E9PPR9 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
161 aa
18.1 kDa
Yes 0
ABI3BP-023
ENSP00000435319
ENST00000527258
H0YEA0 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
191 aa
21.9 kDa
No 0
ABI3BP-026
ENSP00000433981
ENST00000533795
H0YDN0 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
188 aa
20.8 kDa
No 0
ABI3BP-027
ENSP00000437031
ENST00000533855
H0YF18 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
303 aa
32.7 kDa
No 0
ABI3BP-028
ENSP00000431537
ENST00000527943
H0YCG4 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
151 aa
16.4 kDa
No 0
ABI3BP-029
ENSP00000432069
ENST00000528305
H0YCP4 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
125 aa
13.4 kDa
No 0
ABI3BP-030
ENSP00000436070
ENST00000528490
H0YEL2 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
187 aa
20.5 kDa
No 0
ABI3BP-031
ENSP00000434425
ENST00000534256
H0YDW0 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
87 aa
9.3 kDa
No 0
ABI3BP-032
ENSP00000437308
ENST00000534413
H0YF57 [Direct mapping]
Target of Nesh-SH3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
150 aa
16.4 kDa
No 0

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The Human Protein Atlas project is funded
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