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Several cases of colorectal, renal, stomach, pancreatic and liver cancers exhibited weak to moderate cytoplasmic and/or membranous positivity. Remaining cancer tissues were negative.
Weak to moderate cytoplasmic immunoreactivity was observed in few cases of melanomas, breast and pancreatic cancers. Remaining cancer tissues were negative.
The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]