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Most cancer cells were weakly stained or negative. Most testicular and thyroid cancers as well as several pancreatic cancers showed moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
PGGT1B (HGNC Symbol)
Synonyms
BGGI, GGTI
Description
Protein geranylgeranyltransferase type I, beta subunit (HGNC Symbol)
Entrez gene summary
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)