We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cytoplasmic immunoreactivity of varying intensity was observed in liver, pancreatic, gastric and urothelial cancers. Remaining cancers cells were mainly negative.
GENE INFORMATION
Gene name
SPINK1 (HGNC Symbol)
Synonyms
PCTT, PSTI, Spink3, TATI
Description
Serine peptidase inhibitor, Kazal type 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]