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Most cancer tissues displayed weak to moderate cytoplasmic immunoreactivity with additional nuclear staining in a few cases. A single case of papillary adenocarcinoma of thyroid and pancreatic cancer were strongly stained. Several cases of lymphomas, cervical, urothelial and testicular cancers were negative.
GENE INFORMATION
Gene name
BEAN1 (HGNC Symbol)
Synonyms
SCA31
Description
Brain expressed, associated with NEDD4, 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]